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A SPECIAL
ANNOUNCEMENT FROM:
   
 
Waters HDX/MS Solutions
Conformational analysis using Waters HDX/MS technology

Higher Order Structure (HOS) studies are an important part of characterizing biotherapeutic products. These studies go beyond primary structure verification to provide information on protein folding, protein interactions, and aggregation. HOS tools have become indispensable for biotech companies, particularly in the light of recent U.S. FDA guidelines that outline the need for HOS characterization as part of complete characterization of a biotherapeutic or comparability submission for a biosimilar.
Hydrogen deuterium exchange with mass spectrometry (HDX/MS)
Once an impractical technique, hydrogen deuterium exchange with mass spectrometry (HDX/MS) is now more accessible than ever for understanding the impact of conformational changes on safety and efficacy of biotherapeutics.

Waters nanoACQUITY UPLC System with HDX Technology

Waters launched the first commercialized HDX/MS system that was designed through a unique academic/industry partnership. The system leverages UPLC separations with cooled fluidics, high-resolution MS, and robust software that processes, displays, and reports peptide deuterium uptake from even the most complex HDX studies.

The Waters nanoACQUITY UPLC System with HDX Technology delivers answers for the most common questions about biotherapeutic protein dynamics, conformation, and interactions.

Our system solution brings maximum coverage to protein analysis, providing rigorous insight in days compared to other techniques that may take months.

Learn more about Waters HDX/MS technology: Videos, application notes, posters

Anlytical tools
for characterizing biopharmaceuticals
and the implications
for biosimilars
Nature Reviews Drug Discovery, July 2012
by Steven A. Berkowitz,
John R. Engen,
Jeffrey R. Mazzeo, and Graham B. Jones

Nature Reviews: Analytical Tools for Characterizing Biopharmaceuticals and the Implications for Biosimilars

Download article
reprint (pdf)

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