Advances in bioseparations from the biopharmaceutical
knowledge leader - Waters

The annual WCBP conference is a great way to kick off a new year dedicated to biopharmaceutical characterization, and the recent symposium in San Francisco was no exception for Waters.

Glycan analysis
Glycosylation of biotherapeutics is a hot topic as one of the most important critical product attributes for therapeutic safety and efficacy. Just in time to match its scrutiny, Waters announces the availability of the world's first database for glycan analysis by UPLC.

The database will be co-marketed worldwide by Waters and Ireland’s National Institute for Bioprocessing Research and Training (NIBRT).

Developed by Prof. Pauline Rudd's research team at NIBRT, the new GlycoBase 3+ Database is an online resource that contains normalized retention data, expressed as Glycan Units, for more than 600 2-AB labeled N-linked glycan structures. The values were obtained by systematic analysis of released glycans from a diverse set of glycoproteins using Waters UPLC and HPLC technologies. 

• Learn about NIBRT and the GlycoBase 3+ database
  
• Application Note: A Systematic Approach to Glycan Analysis Using HILIC-UPLC and an Online Database of Standardized Values
• Why UPLC and Waters Glycan Separation Technology Columns are unique

Higher Order Structure with HDX/MS
Understanding the impact of conformational changes on safety and efficacy is also an increasingly important part of producing a well-characterized biotherapeutic product, including knowledge of higher order structure. Once an impractical technique, hydrogen deuterium exchange with mass spectrometry (HDX/MS) is now more accessible with new Waters technologies. Our system solution brings maximum coverage to protein analysis, providing robust, rigorous insight in days compared to other techniques that may take months.

• Application note: Localized Conformation Analysis of Mutated Human IgG1
  by HDX MS and nanoDSC
• On-demand webinar: Conformation Analysis of Biotherapeutics by HDX/MS,
  featuring speakers from industry and academia
• Video: See the Waters nanoACQUITY UPLC System with HDX Technology

Waters posters from WCBP
Download our recent posters on topics such as amino acid analysis on the ACQUITY UPLC
H-Class or H-Class Bio Systems, 125Å UPLC size exclusion (SEC) particle columns, a generic UPLC/MS method for host cell protein analysis, glycan analysis, HDX analysis, and affinity purification and MS of mABs using 2D UPLC.

• See full list of posters and download pdfs

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