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Advantages of Size/Shape Ion Mobility Separation for Metabolite ID: Collecting Cleaner and More Specific Data than Using HRMS Alone
 For metabolite identification studies in DMPK, newly introduced MS technologies from Waters enable analytical challenges to be addressed with more speed and confidence using orthogonal size and shape separations. This work demonstrates the ability of the new UNIFI Collision Cross Section (CCS) Research Edition to process ion mobility data generated by the new SYNAPT G2-Si HDMS platform – introduced at ASMS 2013 – in a routine, workflow-driven manner. Also, we demonstrate the utility of ion mobility to provide orthogonal information, enhancing high resolution MS (HRMS) specificity and allowing complex samples to be understood without complication from unrelated interferences.
Waters Pharmaceutical & Life Sciences Team
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