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Featured Application Note:
On-Site Quality Control of Beer
Sonja Schneider, Agilent Technologies
This application note shows the analysis of isohumulones in different beer samples using the Agilent 1220 Infinity Mobile LC solution. Read More |
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GPC–SEC Analysis of Hydroxyethyl Cellulose Used in Pharmaceutical Products
Stephen Luke, Agilent Technologies
Suspension and viscosity–increasing polymer excipients, for example hydroxyethyl cellulose, can be used to uniformly disperse ingredients and maintain suspension so actives do not precipitate or settle under gravity, particularly valuable for liquid formulations during or after manufacture. Read More |
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UHPLC with Light Scattering
Wyatt Technology
The very first multi-angle light scattering (MALS) detector for UHPLC produces SEC–MALS results that rival the best GPC results — with a fraction of the solvent used. Read More |
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Analysis of Complex Petrochemicals by GCxGC–TOF–MS with Select-eV Variable-Energy Electron Ionization
Laura McGregor and Nick Bukowski, Markes International
This application note shows that GCxGC coupled with TOF-MS (BenchTOF) provides a high-performance solution for the characterization of hydrocarbons in complex petrochemical samples. Variable-energy electron ionization technology (Select-eV) is also shown to enhance analyte speciation by providing additional data on both molecular ions and structurally significant fragments in the low-energy mass spectra, permitting robust statistical comparisons essential for successful chemical fingerprinting Read More |
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Automated Solid Phase Extraction and Concentration for the Determination of Nitrosamines in Drinking Water
Phillip Bassignani, FMS, Inc
Nitrosamines are a group of chemical compounds regulated because of their carcinogenic characteristics. Nitrosamines have many sources including widespread usage in the manufacturing of rubber products, as well as cosmetics. They have also been demonstrated to form from reactions between food preservatives and amines. In drinking water, established limits are low (<1 ng/L), requiring detection by a mass spectrometer in the chemical ionization mode Read More |
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Extraction of 1, α25 di-OH and 25-OH -vitamin D2 and D3 from Serum Using ISOLUTE SLE+ Prior to LC–MS–MS Analysis
Alan Edgington, Biotage AB, Sweden
This application note describes a simple, clean, and efficient supported liquid extraction (SLE) protocol for the simultaneous extraction of 25-OH and 1, α25 di-OH-vitamin D2, and D3 metabolites from serum prior to LC–MS–MS analysis. This application note demonstrates high recoveries utilizing a simple PTAD derivatization step after the SLE extraction prior to LC–MS–MS analysis. Read More |
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Automated Solid Phase Extraction and Concentration for the Determination of Nitrosamines in Drinking Water
Phillip Bassignani, FMS, Inc
Nitrosamines are a group of chemical compounds regulated because of their carcinogenic characteristics. Nitrosamines have many sources including widespread usage in the manufacturing of rubber products, as well as cosmetics. They have also been demonstrated to form from reactions between food preservatives and amines. In drinking water, established limits are low (<1 ng/L), requiring detection by a mass spectrometer in the chemical ionization mode Read More |
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Extraction of 1, α25 di-OH and 25-OH -vitamin D2 and D3 from Serum Using ISOLUTE SLE+ Prior to LC–MS–MS Analysis
Alan Edgington, Biotage AB, Sweden
This application note describes a simple, clean, and efficient supported liquid extraction (SLE) protocol for the simultaneous extraction of 25-OH and 1, α25 di-OH-vitamin D2, and D3 metabolites from serum prior to LC–MS–MS analysis. This application note demonstrates high recoveries utilizing a simple PTAD derivatization step after the SLE extraction prior to LC–MS–MS analysis. Read More |
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