Quick LC-MS Method Optimization

The most significant choice in many LC–MS methods is the ionization mode. The generally accepted rule is that electrospray ionization (ESI) works best for higher-molecular-weight compounds that are more polar or ionizable...

Troubleshooting HILIC

Tips to solve common problems encountered with HILIC, such as, insufficient retention, retention time drift, and poor peak shapes.  Each problem is accompanied by an illustration so that you know what to look for in your chromatography. 

Technical Tip -Allowable changes to Pharmacopeial HPLC Methods

Are you taking advantage of the allowable changes to USP methods to speed up or improve the performance of your methods? More importantly - are you falling foul of changes to regulations which restrict changes to gradient USP HPLC methods? Read on to find out more...

Be Afraid.... be very afraid...

A little Halloween fun. See if you can answer these... devilishly difficult killer questions :)

New Free Biochromatography modules

The CHROMacademy biochromatography module will provide a thorough introduction to biopharmaceuticals. Written in conjunction with the Research Institute for Chromatography (RIC) and sponsored by Agilent Technologies.