CHROMacademy

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Fundamentals of LC-MS

4 Video Training Sessions | Running Time 6hr 33min.

Who should take this course

Anyone who is new to LC-MS, or those wishing to develop their practical understanding of LC-MS analysis. All aspects of the technology and system are covered - from an overview of a typical HPLC system and important considerations when combining this separation technique with detection by mass spectrometry, all the way through the various atmospheric ionization processes and the different mass analyzers that are available. Course starts on 7th Sept 2017

Session 1 | Runtime - 123 min.
Understand the fundamentals with

An Introduction to LC-MS - How and Why It Is Used
The Theory of Atmospheric Pressure Ionization Techniques - APCI, APPI, and Electrospray Ionization

Session 2 | Runtime - 114 min.
Learn how ions are detected with the fundamental theory and operation of common mass analyzers

Ion Traps
Quadrupoles
Sector and Orbitraps
TOFs
TQ Experiments

Session 3 | Runtime - 78 min.
Understand the LC side of LC-MS and detect ions by

Considering the Effect of Solvent Type on Ionization
Understanding which Buffers and Additives are Appropriate for Use With MS
Learning How the Detector and Vacuum System Work and How to Keep Them Working

Session 4 | Runtime - 78 min.
Interpret you data and optimize your method by

Understand the Fundamental Concepts of Resolution and Mass accuracy
Gaining Knowledge of Basic Data Interpretation
Learning How to Develop a Method