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In our August issues:

COLUMNS

Sample Prep Perspectives
The Vital Role of Blanks in Sample Preparation
Douglas E. Raynie
Blanks are important in the pursuits of quality control and robust quantitative analytical methods, but many analysts don't fully understand their value, or how to use them correctly.

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Obtain microflow sensitivities with the confidence of analytical flow using Shimadzu's Nexera Mikros UHPLC-MS, which accommodates a wide range of flow rates, from micro (0.1 μL/min) to semi-micro (500 μL/min). A newly designed micro ESI source provides greater than ten times the sensitivity of standard UHPLC-MS systems. The system's unique UF-Link allows operators to correctly and easily connect any microflow column.
Learn more.
LC Troubleshooting
Contaminants Everywhere! Tips and Tricks for Reducing Background Signals When Using LC–MS
Dwight R. Stoll
We examine instances where contaminants are problematic in LC–MS, as well as successful methods to decrease their influence.

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Rapid Low-level Identification and Quantitation of Host Cell Proteins
Europe: Thursday, September 6, 2018 at 2pm BST | 3pm CEST
North America: Thursday, September 6, 2018 2pm EDT | 1pm CDT | 11am PDT
Asia Pacific: Friday, September 7, 2018 at 11am CST | 12pm JST | 1pm AEST
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Perspectives in Modern HPLC
Ten Common-Sense Corollaries in Pharmaceutical Analysis by HPLC
Michael W. Dong
These ten propositions are widely acknowledged, but frequently neglected, by practitioners of high performance liquid chromatography (HPLC).

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Natural Product Purification by Centrifugal Partition Chromatography (CPC)
Tuesday, August 28, 2018 at 11am EDT | 8am PDT | 4pm BST | 5pm CEST
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The Essentials
Advantages of Supported Liquid Extraction
We look at a process that can overcome the shortcomings associated with liquid–liquid extraction.
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PEER-REVIEWED ARTICLES

Frontiers in Ultrafast Chiral Chromatography
Daipayan Roy, Choyce A. Weatherly, M. Farooq Wahab, and Daniel W. Armstrong
We explore the developments that have made it possible to produce sub-minute, and, more recently, even sub-second enantiomeric separations.
We also look at the questions that remain unanswered.

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Improving GC Quality and Quantitative Analysis Accuracy and Throughput Using GC-VUV
Wednesday, August 22, 2018 at 11am EDT | 8am PDT | 4pm BST | 5pm CEST
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Biomimetic Chromatography to Accelerate Drug Discovery: Part II
Klara Valko
Biomimetic HPLC retention data can be used to measure how a compound will bind to proteins and phospholipids in vivo.

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Data Integrity in the Chromatography Laboratory, Part V: Second-Person Review
Mark E. Newton and R.D. McDowall
The series continues with a crucial scientific and regulatory necessity in ensuring reliable information—the second-person review.

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Chromatography Fundamentals, Part IV: Origin of Theoretical Plates—Fractional Distillation and Countercurrent Distribution Extractions
Howard G. Barth
The theoretical plate concept forms the basis of chromatographic theory. Here is where it came from.

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WEBCASTS
Part 2: A Collaborative Approach for Successful Method Transfers and Routine Quality Control Batch Release Testing
Tuesday, August 21, 2018 at 11am EDT | 8am PDT | 4pm BST | 5pm CEST
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Critical Evaluation of HPLC Methods
Thursday, August 16, 2018 at 11am EDT | 8am PDT | 4pm BST | 5pm CEST
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Eliminating Toxic Contaminants from Cannabis Extracts Using Proven Chromatography Purification Methods
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A Short Journey to Bio/Pharmaceutical UHPLC Method Transfer Success
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Better Characterize Your New Biologics with Robust High-Resolution Charge Heterogeneity Analysis
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If you would like to submit an article to LCGC, contact Laura Bush, Editorial Director - [email protected]

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