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Forensic Analysis Using the GCxGC–TOF MS
Laura McGregor, David Barden and Nick Bukowski, Markes International
Trace-level forensic analysis of lachrymators (tear gas) in contaminated clothing is achieved using GCxGC-TOF MS, which provides a high-performing combination of sensitivity, spectral quality, and chromatographic resolving power.
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Bornyl Acetate Chiral GC Separation
Mario Galli and Stefano Galli, MEGA s.n.c.
Bornyl acetate is an important chiral compound that can be found in many samples, including essential oil of Lavender. We present a new chiral cyclodexstrine-based phase for the chiral gas chromatography (GC) separation of the two enantiomers of bornyl acetate, as well as many other chiral compounds that are of interest to the flavours and fragrances industry. Download the app note |
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The Analysis of Chlorinated Dioxins, Difurans, and Polychlorinated Biphenyls in Edible Oils
Phillip Bassignani, FMS, Inc.
The dioxin family consists of 210 compounds, of which 17 contain the 2,3,7,8 pattern of chlorination. These 2,3,7,8-containing compounds are of extreme concern to human health because of their high level of toxicity. Approximately, 12 of the 209 polychlorinated biphenyls have also been identified as human toxins. For this reason, the US FDA and EU have established strict regulations for the monitoring of food products for human consumption, in particular edible oils. Manual extractions of oils can be a time-consuming procedure often delaying lab turnaround times. By automating the process with the PowerPrep®, food oil samples can be reliably processed with routine 24 h turnaround times. Download the app note |
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Quantitative Analysis of Anabolic Steroids in Urine using Mixed-Mode SPE and LC-MS-MS
Jody Searfoss, UCT, Inc.
Anabolic steroids are man-made substances related to endogenous testosterone. They are prescribed to treat delayed puberty or diseases that cause lean muscle loss. They are also abused in attempts to enhance athletic performance. Steroids are excreted as glucuronide or sulphate conjugates. This method describes a mixed-mode SPE extraction of steroids from urine. Excellent linearity and recoveries were achieved for 12 steroids. Download the app note |
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SEC-Light Scattering for Antibody Drug Conjugate Characterization
Wyatt Technology
the factors critical to effective ADC design is the drug antibody ratio (DAR). The DAR describes the degree of drug addition, which directly impacts both potency and potential toxicity of the therapeutic, and can have significant effects on properties such as stability and aggregation. Determination of DAR is, therefore, of critical importance in the development of novel ADC therapeutics. We present here a method for DAR determination based on SEC-MALS in conjunction with UV absorption and differential refractive index detection. Download the app note |
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Measuring protein molecular weight using the Viscotek SEC-MALS 20 and Waters Empower®
Malvern Instruments
Protein activity is often defined by its molecular weight and aggregation state. In this application note, we show how the Viscotek SEC-MALS 20 detector can be used in combination with Waters Empower® software for the measurement of protein molecular weight, and oligomeric or aggregation state. Download the app note |
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Quantitation by High Resolution Mass Spectrometry
Yun W. Alelyunas, Mark D. Wrona, Russell J. Mortishire-Smith, Nick Tomczyk, and Paul D. Rainville, Waters Corporation
With its powerful multiple modes of data acquisition and the superior acquisition speed, time-of-flight MS (Tof MS) platforms have aided scientists in their various research activities. For quantitative analysis, Waters has introduced a new target-enhancement mode of data acquisition, Tof-MRM, on the Xevo G2-XS and SYNAPT G2-S HDMS mass spectrometers. Download the app note |
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