The study of protein binding is of importance in elucidating their interaction with a variety of target molecules. Recently there has been interest, especially from the health point of view, in the study of phenolic compounds. This principally stems from their antioxidant activity with potential health benefits. One set of compounds that have attracted interest are curcuminoids. Often in biological and synthetic study it is not possible to obtain large quantities of material, so the ability to measure small measurement volumes is needed. Here the rapid and efficient acquisition of fluorescence decays on the millisecond timescale is used to study the interaction between curcuminoids and human serum albumin occurring in a measurement volume of 5 µl.
 
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